At the Wortzel Lab, we investigate how cancer cells communicate with their environment through extracellular vesicles (EVs), with a particular focus on DNA associated with EVs. Our research uncovers how EV-DNA shapes tumor–immune interactions, influences anti-tumor immunity, and affects metastatic progression. By combining advanced genomics, imaging, and in-vivo cancer models, we aim to decode the molecular mechanisms governing EV-DNA biology and leverage this knowledge to improve early detection and develop new therapeutic strategies against metastasis.