Welcome to Wortzel Lab, Tel Aviv University

At the Wortzel Lab, we investigate how cancer cells communicate with their environment through extracellular vesicles (EVs), with a particular focus on DNA associated with EVs. Our research uncovers how EV-DNA shapes tumor–immune interactions, influences anti-tumor immunity, and affects metastatic progression. By combining advanced genomics, imaging, and in-vivo cancer models, we aim to decode the molecular mechanisms governing EV-DNA biology and leverage this knowledge to improve early detection and develop new therapeutic strategies against metastasis.

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Our Research Focus

EVs carry a wide variety of biomolecules, including DNA. We study the biology and function of EV-associated DNA (EV-DNA) in cancer progression and metastatic defense: how chromatinized DNA is packaged into EVs, how recipient cells detect and respond to it, and how these signals reshape local tissues and systemic immunity

Explore Our Research

Meet the Research Team

Discover Our Publications

Summing up Prof. Lyden's Visit Summing up two days of Prof. David Lyden, our scientific Godfather, visiting Israel and our lab.	Interacellular Dialogue WIZ Dr. Wrotzel presenting her discoveries at the WIZ Intercellular Dialogue in the Tumor Microenviorment. What a day of interesting and innovative research talks	Woman and Girls In Science Day Our lab is Proud to be one of three labs chosen to appear in TAU's Woman and Girls In Science Day, You can read all about that in the article!	Hands On PI!! Dr. Wortzel one-uping all the other PIs and doing some hands on teaching to her research students
Thank you TAU.nano! Closing a great workshop involving many researchers from the Koum center for nanotechnology all handling nano-particles in some way.	We Arrived! the 14th annual Nano-Center Workshop we are here, now you can start	The most popular speaker Dr. Wortzel wowing the crowd with her talk on EV-DNA	More Glisons! We are keeping our high standard. Aml receiving her new set of Gilson Pipettes
View From Our lab Make sure to look outside between assays!	Welcome Aml Welcoming our newest team member Aml. We keep moving forward	Gilson Pipettes Only the best for our lab! Exited to receive our Gilson Pipettes	Starting Off Started receiving reagents and prepping for assays
First Team Lunch So exited to kick off with a full team ready for research	ZetaView Partical Metrix's advanced NTA system is here and ready